BETHANY BUCK

The primary focus of our research is to utilize a multidisciplinary approach incorporating structural biology, biophysics, biochemistry, molecular biology and cellular biology to investigate mechanistic questions in the area of transcriptional regulation. We have had a long-standing interest in applying these methodologies to discern structure-function relationships for specialized transcription factors that recognize epigenetically modified methyl-CpG DNA sequences. More recently, through collaborative efforts, we have expanded our program to mechanistically interrogate the molecular mechansims by which proteins recognize poly(ADP-ribose)-chains and G-quadruplexes to mediate DNA damage response and transcriptional processes.